How CBD Works - How does CBD work for inflammation
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It's the Goldilocks scenario.
A little inflammation is fine.
It's actually an important tool of our bodies to not only protect us from foreign intruders but to rebuild tissue.
The problem is when it doesn't get turned off.
Or worse yet...attacks our own tissue!
That's where we get into trouble and most major diseases are intimately tied to inflammation.
Maybe some that you wouldn't expect.
Just recently, a study link immune response from psorriasis treatment to cardiovascular disease.
What's the connection?
If you read trough this site, you'll see they're playing catch up.
Sure, we can guess a connection with arthritis or gut issues.
That makes sense.
Which begs the question...why is our body's inflammatory response so under fire?
Great question and we'll touch on that below.
We'll also look at how CBD might just be the biggest and newest ally in our fight against the "wrong" kind of inflammation.
Research research research.
We'll look at all of it.
If you want to see the CBD oils that are screened for safety and value, you can go here:
Otherwise, jump to any section of interest here:
Let's get started.
People (and marketers) throw the work "inflammation" around like it's a tangible thing.
What is inflammation in the body?
First, inflammation is a product of the body's immune system.
That's where we come in contact with the outside environment most directly (via food).
Viruses, bacteria, mold, and all sorts of poisons are hitchhiking with our food.
There's no way around that.
So the immune system is on constant alert to go after anything that might be dangerous to us.
It has a number of weapons to send:
We won't get into the full arsenal that the body use but inflammation is a response to one of two things:
The two different targets shed some insight into both the positive and negative aspects of inflammation.
On one hand, if our immune response doesn't win, we don't survive.
However, within the inflammation itself are powerful chemicals the body uses to rebuild and repair (for example, after injury).
The anti inflammatories are doing just that...cutting the inflammation process short but therefore bypassing the needed substances for correct repair of the actual tissue.
So, we need inflammation. It's important to our survival and success!
So why all the hubbub about inflammation?
Think of inflammation as any army.
It will also cause some damage to our own surrounding tissue.
This is a sad fact of war even within our own bodies.
Sometimes, the immune system goes haywire and attacks everything!
In fact, it can even target our tissue directly.
That's the basis for every autoimmune disease:
Pick an organ or system in the body and there's probably a disease where our immune system mistakenly attacks it.
It's weapon of choice?
Why is the body's immune system going out of whack so often these days?
Take a look at around you right now.
Keep in mind that the immune system has been slowly crafted by trial and error for millions of years.
It's enemies have been pretty consistent over that time.
It knew the usual cast of bacterial and viral characters.
New ones would pop up occasionally but for the most part, it was business as usual.
Enter the new age of chemistry.
You are surrounded by:
The immune system is taxed.
It's downright flipping out!
It has to assess and respond to all these new actors on the scene.
It is not succeeding.
Just a few examples (of 1000's) to bring home the point:
A recent report showed a link between the Gardesil HPV vaccine and MS in teens.
Albeit a small sample, this follows a wider French study showing the potential link with GBS, a disease where the immune system attacks nerves.
A new study showed a tie between long term use of ACE inhibitors, a very popular blood pressure medicine given to millions, and lung cancer.
The mechanisms isn't known yet but there's a clear tie between certain cancers and inflammation (see CBD and cancer page).
Antibiotics used in food has shown a relationship with obesity as they impact the gut bacteria which are starting to appear at the center of everything these days.
Or at least, not at the levels sent its way.
It starts in utero.
Glyphosate, like most pesticides, is a neurotoxin. That's how it kills pests.
Unfortunately, we use the same pathways for passing messages and developing brains.
Guess what system has to clear all this out.
The immune system.
It's primary weapon of choice?
So...what does any of this have to do with CBD and the endocannabinoid system?
We thought you would never ask!
First, some background please!
The endocannabinoid system runs through all our bodies.
All mammals in fact!
Research shows that it is responsible for balancing three key systems at least:
These systems are incredibly complex and they all interact with each other.
In terms of inflammation, the immune system is our first go to but don't discount hormones and neurotransmitters.
It's a symphony of chemistry that delicately balances between too little and too much at each choke point.
Most of our modern living (chemicals, antibiotics, pesticides, etc) falls on the immune system.
Here's a quick image:
We have two types of cannabinoids.
They all interact with this one system and the current thought is that CBD and outside cannabinoids are used as needed by the system when it runs low.
We'll leave you with this summary before getting into research:
And since research is only now ramping up...
The endocannabinoid system is intimately tied in with the inflammatory process.
Let's dig directly into the research data on cannabinoids and CBD specifically for inflammation.
Data is pointing to CBD being a very powerful anti inflammatory in the body.
This research gives a fascinating review of CBD's effects on inflammation across an array of issues:
Look at the sheer breadth of effects the endocanninoid system is affecting!
That's why it is so exciting.
We're talking about a difference in kind versus scale.
The endocanninoid system appears to sit up above the sub systems we're bashing about with our current medications strategy.
Enough generalizations...let's look at research.
Everything else is just marketing.
We're going to bounce around the body and brain.
Let's take a journey.
We'll start in the gut...where the immune headquarters reside and inflammation "decisions" are primarily made.
Otherwise, they build up there and cause inflammation.
Let's put a checkmark next to possibly helping IBS, GERD, Crohns, Colitiis, etc.
Bringing down inflammation in the gut goes a long way towards lowering it throughout the body.
You can learn all about CBD and autoimmune here.
We'll wrap this section with why that's true according to research later.
First, cannabinoids help to manage the creation/death of immune cells which is important.
Too much of a good thing can be bad....and end in things like psoriasis.
Remember...we're looking for balance.
Let's look at actual results please.
We'll start with specific actions of CBD on the inflammatory pathway.
First, its effects on the inflammatory pathway in pancreatitis
IL-6 and Tumor Necrosis Factor are both markers of inflammation.
That's a good start.
Next, CBD appears to reduce inflammation resulting from lung injuries via a specific pathway:
Next, it goes after chronic and neuropathic inflammation and pain via an entirely different pathway:
Keep in mind that inflammation is often associated with pain and some diseases are the direct result of inflammation in the nervous system itself.
That's good news for people with fibromyalgia, diabetes, and Parkinson's.
Looking at ulcerative colitis, an entirely different pathway for inflammation involving the glial cells (immune cells in the nervous system which extends to the gut as well).
Let's jump from the gut an nervous system to the eyes.
Eye retinosis in diabetics to be exact...
Umm...that's the leading cause of blindness. Why isn't this front page news!
Let's jump from the brain to an organ with some importance...the brain!
What about Alzheimer's and Dementia inflammation?
Even more amazingly....
That's science speak for "building new brain". In the hippocampus, a ridiculously important area for memory, emotions, and motivation.
Raise your hand if memory, emotions, and motivation are important to you!
We looked at brain, what about heart and arterial health.
Endothelial cells line the interiors of blood vessels and lymphatic vessels, the first being root of cardiovascular issues.
CBD brought down the inflammatory response to high sugar (important for diabetics specifically but for heart health more generally).
Remarkably, all the above mentioned effects of HG were attenuated (reduced) by CBD pretreatment.
What about the inflammation that follows acute injury and of course the accompanying pain?
Hyperalgesia is pain response.
The word they used was "abolished".
Pretty bold for researchers who prefer the more demure "attenuated".
Cancer is nasty business.
Aside from the inflammation requirement for many cancers, there's the current treatment of it which can include very toxic radition and chemotherapy agents.
How about CBD to counter this intense inflammation in health tissue including kidney failure and inflammation overload?
Remember how we talked about inflammation is needed to rebuild tissue?
NSAID's can alter the correct repair matrix in this process.
CBD works along a different pathway and is showing positive effects in regards to "fibrosis" or scarring.
The "resolution" of inflammation is important.
Remember the issue with "chronic inflammation"??
Resolution refers to the "shutting" down of a specific inflammation response.
That's good new for all types of fibrosis and should be researched further for cystic fibrosis.
What about the worst inflammation out there...that which is tied into demential and Alzheimer's?
Good news there in CBD removing inflammation that drives build up amyloid plaques.
The AÎ² above is amyloid beta protein, the precursur to the plaques.
Did we just read that right?
YOu can check out the research on CBD and Alzheimer's and Dementia here.
CBD shows promise in bringing down brain inflammation across the board which has important considerations for a slew of terrible diseases:
That list of nasty sounding words are some of the immune response actors that cause damage when excessive.
Staying with the brain, CBD helped to reduce imflammation for autoimmune encephalomyelitis
We only covered a few examples of research regarding CBD and inflammation.
The idea is to show that CBD's effect appears to be systemic.
Active on the entire system.
The pathways and actors can be different (glial cells in the brain, mast cells in the gut, T cells in the blood) but the net effect was the same.
We'll leave you with this.
A recent study shows that CBD turns the immune response from a T1 (aggressive, attack) to T2 (stand-by, calmer) in the gut!
We end where we started. In the gut.
This is headquarters for for inflammation.
CBD may have its greatest effect there. We'll have a CBD and the gut article soon!
This depends on what we're trying to address.
General inflammation may require a maintenance dosage of CBD.
Keep in mind that CBD has been tested up to 300-600mg doses for most of the research above.
It's even been tested up to 1500mg with a strong safety profile.
You can learn more about CBD's safety here.
If your inflammation is specific to a condition, higher doses might be more helpful.
Keep in mind that CBD has not been cleared by the FDA to treat diseases or ailments.
Here's a quick look at dosages:
Make sure to let others know what works for you here.
It's important to share what works with others!
We want very clean CBD:
Otherwise, we're just taking a bunch of olive or coconut oil!
The CBD oils are the most popular for inflammation unless the issues is specific to the skin or a given area (such as sprained ankle, etc).
The oil is systemic - works throughout the body which is important.
You can see the best priced CBD products here based on 3rd party testing:
You can also see the CBD comparison here.
Again, please let us know your results so we can publish them (anonymously) for others to learn from!
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others to learn
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