None of the statements on this website have been evaluated by the United States Food and Drug Administration. CBD products are not intended to diagnose, treat, cure, or prevent any disease. A doctor's advise should be sought before using CBD products especially if you have a serious medical condition, use prescription medications, are pregnant, or are nursing a child.
We've covered anxiety in-depth already.
Let's talk about the twin issue of depression and CBD.
50% of people that experience one also gets hit with the other. They can go hand in hand with.
"Hit" is the operative word. It's a brick wall!
For anyone who has suffered or known someone close who has, it's a tremendous level of hardship.
15% of people will experience an episode of major depression during their life and that's probably underrated.
People still feel a tremendous amount of shame and stigma from depression which doesn't make sense!
It's just chemistry.
I know first hand as I've seen the most upbeat person for 20 years get hit with about during perimenopause.
As she put it, no amount of talk therapy, medication, or exercise was going to cut through the wall of hormones and neurotransmitters that were in flux.
Like fighting the tide.
And we tried everything!!
Nutrition is driven by genetic data (B Complex, Magnesium, Choline, MTRR, COMT, etc)
Various supplements (5HTP, Acetyl L Carnitine, St John's Wort, Theanine, etc)
Lifestyle changes (daily exercise, tai chi, medication, lost weight, organic eating, probiotics, etc)
We saw the effect first hand but we want research!
First, let's look at the enemy....depression itself.
A Quick Look At Depression
It's amazing that we work at all.
The number of things that have to fire off at just the right amount and just right time...millions of time a second...in billions of cells!
Just in your brain!
Now, we need to look at actors involved in the dance of feeling all right.
Depression doesn't mean anything's wrong with you.
It just means that chemistry isn't happening in the body and brain at the ideal level.
We're not talking about the occasional "feeling down" periods which we all get.
This is more oppressive.
Something just isn't flowing correctly.
Before we get into CBD, we'll look at what's going on with depression.
Healthy mental functioning is a result of a careful dance between two and maybe even three subsystems:
Nervous system – neurotransmitters
Endocrine system – hormones
Gut or Immune system – neurotransmitters, gut biome, and inflammatory actors
Those are big systems with different actors that are in a constant dance or...battle!
The body and brain work this way.
There some actors that will boost a given effect while others will reduce it.
Too much can be bad (mania for example) while too little can be bad (depression).
It's a constant tug of war and various tripwires and checks/balances.
We win when the two sides of a given partnered pair are in balance.
Balance. Homeostasis (a big work to mean in a stalemate...balance).
Remember those words...they're really important for CBD and depression.
So who are the actors?
Neurotransmitters – Serotonin, norepinephrine, glutamate, and dopamine
Hormones – Progesterone, Estrogen, and Testosterone
A quick (very) synopsis of the most critical actors for depression.
Serotonin is your general "feel good" hormone. It's a MAJOR player.
Norepinephrine is your adrenalin transmitter but it's important at smaller levels
Dopamine is your reward hormone. Feeling joy in doing something!
Glutamate is interesting...it's excitatory...the opposite of "blahhh"
Progesterone is the mother of hormones and generally has a calming effect.
Estrogen (even men have it) interplays with the other hormones and neurotransmitters
Testosterone imparts a zest for life and also a "devil may care" effect
All of these chemicals (and many others) have to balance out to feel "right".
The neurotransmitters are operating on a timescale of 1000's of a second.
The hormones are operating longer term and even cyclically (day/night, monthly, etc).
Either way, this is a rich symphony of chemical sound where every instrument has to play at the right time, in the right note, and with the right pauses.
Again...it's a miracle we can even get up in the morning.
Let's address why sometimes we can't. Depression.
All of these chemicals have to be in a certain balance. Homeostasis.
There are mechanisms in the body to adjust when there's an outside influence (a tuba in the audience starts playing).
This could be a million things:
Stress in life
Natural substances in our food
Sun, rain, wind, and elements
Heat, Cold, Seasons, Etc
Those are the basics we should interact with. Our bodies have had a few million years to adjust to those.
Let's fast forward to the last 50 years.
Here's the issue.
Let's now throw this chemical symphony into a sea of new chemistry:
Endocrine (hormone) disruptors in food and plastics
Toxic chemicals found in our blood now (DDT, fire retardant, etc)
Pesticides and food contaminants (glyphosate, DDT, antibiotics, etc)
Heavy metals (arsenic, lead, etc)
We all have this in our bodies now.
In fact, a study of umbilical cord blood found 287 chemicals present:
Among them are eight perfluorochemicals used as stain and oil repellants in fast food packaging, clothes and textiles including the Teflon chemical PFOA, recently characterized as a likely human carcinogen by the EPA's Science Advisory Board – dozens of widely used brominated flame retardants and their toxic by-products; and numerous pesticides.