How CBD Works - How does CBD work for diabetes
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Almost 10% of the US population has diabetes.
That’s a crazy number considering the cost, suffering, and effects on health.
That’s over 1 million people who are being told their body is no longer correctly processing sugar.
We immediately go to food and exercise.
Get in line diabetes…all our modern diseases are autoimmune.
Turn on the TV and the pharma ad that shows will likely be for autoimmune disease.
It’s big business.
Billions of dollars and the side effects are nasty!
What the ads won’t tell you…autoimmune is right in CBD’s wheelhouse!
It’s one of the three major systems that the endocannabinoid system helps to regulate.
Let’s dig deeper into this.
If you just want to get started with screened CBD, go here:
Otherwise, get ready to learn about the amazing research on CBD and diabetes.
Jump to any topic here:
Just a refresher course so we can get to how CBD works with diabetes.
There are two types of diabetes (Type 1 and 2) but the second is more prevalent.
That’s the one that is acquired over time whereas Type 1 is congenital which means you’re born with it.
They both involve the islet cells in the pancreas which release a hormone, insulin (among others).
Insulin is an important hormone that governs how sugar is used in the body.
If there’s not enough insulin, sugar builds up in the bloodstream and it’s pretty toxic to tissue in the body.
All kinds of very serious issues arise from this sugar overload
The issues affect every part of the body since sugar overload is systemic.
What happens to cause this failure in the pancreas and throughout the body?
Let’s first answer a few questions, shall we!
For most people, yes.
Add this to the list of most modern diseases where our immune system is going haywire.
Instead of the joints like arthritis, the immune system is attacking the pancreas where islet cells reside.
Quick refresher…we’re swimming in a chemical soup…many of which disrupt or mimic hormones.
There are some important hormones that need to work pretty precisely for our body’s usage and maintenance of sugar in the body.
FYI…insulin is a hormone!
In case you’re fluent in Klingon, let’s throw in some other hormones key for proper sugar management:
All intimately involved in diabetes.
There’s that word..again…balance.
It is tied to being overweight so the thought is that too much sugar basically overran the insulin process.
There’s research pointing to it also having autoimmune and inflammatory roots as well:
Signs of the inflammation are being directly viewed:
We’ll look at this later but let’s not jump the shark…
Are there even CBD receptors in the pancreas?
There seems to be CB1 or CB2 receptors almost everywhere we look in the body.
Like we’ve said…the endocannabinoid is system-wide!
CB stimulation affected the levels of both insulin and glucagon.
So there’s something there.
Furthermore, the main endocannabinoid (naturally in our body) 2-AG was managed by…
Wait for it…
So the endocannabinoid has its signature all over the insulin/glucagon/sugar enterprise.
What might be going on there?
The endocannabinoid system runs through your entire body.
Research shows that it helps to balance other key systems in the body:
The receptors are everywhere…brain, skin, blood, and even the pancreas!
Here’s a quick look at it in the body:
If diabetes is a function of an inflammatory response (immune system) run amok which affects the function of hormones (insulin, glucagon, etc) then…
CBD is readily available fuel for this system when it gets overwhelmed (which it is in our modern world of chemical soup).
So…what does research find regarding CBD and diabetes directly.
We’re ALL about the research.
Everything else is just marketing!
Here we go.
So we determined that CBD receptors (both CB1 and CB2) are functioning in the pancreas and affecting the intended hormones.
That’s a good start.
Before diving into specific research on CBD (blood sugar, brown fat, etc), let’s look at some summary level research first.
First, here’s a fascinating and complete overview of the process of obesity and diabetes with its impact on the endocannabinoid system.
A few important highlights:
So…the endocannabinoid system helps to regulate energy and fat.
This obviously plays into the process of Type 2 diabetes where 80% of the sufferers are obese.
It goes on to say…
Adipogenesis is just a fancy word for creating new fat.
What’s the fancy word for dropping 10 pounds. Enough about me…
There is a lot of info in this article but when it comes to diabetes:
That basically sums up what we stated originally!
This is all great but what are the results with people.
Good news there.
Across obesity, energy update, lipid profile, and everything else.
Specifically for diabetes…
There’s lots of research that points to a similar cause-effect between a disturbed endocannabinoid system and diabetes.
Also, there’s that whole inflammation pathway popping up again:
If we need a silver bullet for this argument…we’ll leave you with this…
Anandamide is our naturally created endocannabinoid.
Guess what CBD does in terms of Anandamide…
Drop mic. And Out!
On a side note, the article is interesting in that it’s finally tackling the gut biome and its importance in our health.
Take that processed foods and added chemicals, preservatives, colors, and fake sugars.
Let’s look at specific aspects of diabetes and CBD.
First, what about all the other obesity and diabetes drugs versus CBD.
Some interesting results on the cannabinoids.
Without all the nasty side effects.
CBD’s safety profile is very strong.
See Is CBD Safe here.
Let’s take an example…the “blockbuster”� diabetes drug Trulicity.
First, check out the side effects here and scroll down to some of the nastier ones.
According to their site, Trulicity acts like our natural hormone GLP1.
You know what research is showing that also acts on GLP1 (plus the other hormones that are key to the whole energy/sugar process)…
You guess it.
This is one example but what a powerful one in terms of where our healthcare system has gone!
CBD is the primary, non-psychoactive cannabinoid we can use to feed our naturally occurring system.
Make sure to speak with your doctor for diabetes or obesity treatment but also make sure to be your own advocate!
Let’s dig into individual aspects of CBD and obesity.
We have an entire article on CBD and obesity, weight loss, and healthy weight management.
Just some highlights here as it pertains to diabetes.
There’s a great overview of the intersection of these related topics here:
Okay…so the endocannabinoid system is intimately involved in the obesity process.
We have a suspect!
There may even be a genetic component of the endocannabinoid system that affects obesity and diabetes:
SNP is short for mutations in single genes that cause different effects (both good and bad).
They’re basically saying that mutations in endocannabinoid genes can result in problems with energy and sugar processing in our bodies.
Keep in mind that glucose or sugar is the most common fuel used in the body.
We need it for energy, to power the cell’s activities.
There’s new research on an important new channel called TRPV1.
You need energy homeostasis (balance) to maintain a healthy weight.
The TRPV1 channel has been shown to affect this balance and guess what manages it?
The endocannabinoid system!
It’s pretty detailed but a quick synopsis:
Let’s first start with insulin sensitivity which is at the heart of Type 2 Diabetes.
That’s good news.
Insulin “insensitivity”� is at the root of diabetes.
Anecdotally, there are many reports on people lowering the A1C results with just CBD.
Many people use CBD not just for the core inflammation that lies at the heart of diabetes but also for the complications that result:
There’s good news on that front as well!
CBD has been shown in research to be neuroprotective!
All that sugar in the bloodstream is toxic to our tissue.
Here’s an example:
Specifically, CBD reduces the oxidative stress:
There’s a (very) comprehensive article on CBD and diabetes complications here:
In this exhaustive paper, they cover cannabinoid’s positive effect on:
The net net…
Music to our ears (and pancreas!)
Brown fat is the new black.
It’s all the rage in obesity and diabetes corners.
Or just healthy weight loss in general!
Babies have it and only recently, it was discovered in adults as well.
There appears to be a tie-in between CBD receptors and brown adipose fat (BAT):
In fact, they partially used CBD receptor activity to find brown fat in the body since the two are linked:
We expect more information on this front over time.
Brown fat is good!
We’ve shown the research on CBD and Cancer here.
For pancreatic cancer, there’s specific research.
Apoptosis is a fancy way to say cell death.
If the cell is cancerous, that’s good news
Check out the full article on cancer.
We need more research.
No one who is a responsible actor can say that CBD cures diabetes.
So…what ARE researchers (not marketers and advertising types) saying?
Okay…so he said cure. He is a researcher and doctor so we’ll let him deal with the FDA.
But how exciting if new research bears this out!
We already mentioned how CBD impacts the same diabetes pathway (GLP1) as the newest blockbuster diabetes drug above.
Animal models are pointing to the prevention of diabetes as a start:
Clearly, something is going on here.
Hurry up researchers…we need you!
Make sure to check out our CBD dosage guide here.
It partially depends on the severity of what we’re trying to address.
The general rule of thumb is to start small and see how your body responds.
It has been tested between 300-600mg/day with a strong safety profile.
There are even studies with up to 1500mg doses and little side effects
Here’s a general guide.
A CBD isolate might be the best approach to start.
We hate to see people miss out on the benefits of CBD due to the other plant materials in full spectrum.
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